Tadalafil: Everything You Need to Know About This Popular ED and BPH Treatment
What Is Tadalafil? (UK Guide)
Tadalafil is a prescription medicine, classified as a phosphodiesterase type 5 (PDE5) inhibitor, mainly used to treat erectile dysfunction (ED, impotence) and the symptoms of benign prostatic hyperplasia (BPH) in men. Marketed under familiar brand names like Cialis, as well as generic forms, Tadalafil has revolutionised sexual health and urology since its approval by regulatory agencies such as the MHRA (UK Medicines and Healthcare products Regulatory Agency) and the EMA (European Medicines Agency).
How Does Tadalafil Work? (Mechanism of Action Explained)
Tadalafil works by increasing blood flow to the penis, making it easier to achieve and maintain an erection when sexually aroused. It does this by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which regulates blood flow in the penis. Additionally, in cases of BPH, Tadalafil helps relax the muscles in the prostate and bladder, making urination easier and reducing the symptoms of urgency and frequency.
- Class: PDE5 inhibitor
- Common brands: Cialis, Adcirca (for PAH), generic Tadalafil
- Prescription required in the UK? Yes
- Used for: Erectile dysfunction (ED), Benign prostatic hyperplasia (BPH), and sometimes Pulmonary arterial hypertension (PAH)
Why Is Tadalafil So Popular? — The “Weekend Pill”
Unlike Sildenafil (Viagra), Tadalafil is known as the “weekend pill” due to its long duration of action. A single dose can last up to 36 hours, offering more flexibility and spontaneity. This feature, along with its established safety profile, has made it a first-choice treatment for many UK men and their partners.
Infographic: At a Glance — Tadalafil vs. Other ED Medications
| Medication | Onset of Action | Duration | Food Interaction |
|---|---|---|---|
| Tadalafil | 30–60 min | Up to 36h | Minimal |
| Sildenafil (Viagra) | 30–60 min | 4–6h | Best taken on empty stomach |
| Vardenafil | 30–60 min | 4–6h | Affected by fatty foods |
How to Take Tadalafil Correctly
Recommended Dosages
- For Erectile Dysfunction (ED):
- Take 10 mg before anticipated sexual activity, at least 30 minutes prior.
- Adjustable (as low as 5 mg or up to 20 mg), depending on efficacy and tolerance.
- Do not take more than once per day.
- Alternatively, a daily dose regimen: 2.5 mg or 5 mg taken at the same time each day for men with frequent sexual activity.
- For Benign Prostatic Hyperplasia (BPH):
- Typically 5 mg taken once daily, at the same time each day.
How to Use (Step-by-Step):
- Take Tadalafil with or without food (large meals are okay).
- Swallow the tablet whole with water.
- Do not break, crush, or chew.
- Allow at least 30 minutes for the medicine to work.
- Sexual stimulation is required for effect.
Who Should Use Tadalafil? — Indications and Eligibility
Tadalafil is indicated for:
- Men (aged 18+) with erectile dysfunction (ED)
- Men diagnosed with both ED and BPH
- Men with lower urinary tract symptoms associated with an enlarged prostate
- Occasionally prescribed for pulmonary arterial hypertension (at different dosages)
The medicine is not normally used in women or in children.
Who Should NOT Take Tadalafil?
Do not use Tadalafil if you:
- Take nitrate medication for chest pain or heart problems
- Have severe heart or liver problems
- Recently had a stroke or heart attack
- Have low blood pressure or uncontrolled blood pressure
- Are using recreational drugs called “poppers” (amyl nitrite, etc.)
Consult your doctor for a full screening.
Tadalafil Side Effects: What to Watch For
Like all medicines, Tadalafil can cause side effects. Most are mild and pass quickly, but some require medical attention.
Common Side Effects (Affecting up to 1 in 10 people)
- Headache
- Indigestion or heartburn
- Back pain
- Muscle aches
- Blocked or runny nose
- Flushing (red face)
Uncommon or Serious Side Effects
- Allergic reactions (rash, swelling of face/lips/throat)
- Prolonged or painful erection (priapism)
- Sudden vision or hearing loss (rare)
- Chest pain — seek medical help immediately
Interactions to Avoid
- Nitrates (GTN spray, isosorbide mononitrate, etc.)
- Alpha-blockers for blood pressure or prostate
- Certain antifungal medicines and antibiotics
- Alcohol: increases risk of low blood pressure
Doctors’ Insights: Expert Comments on Tadalafil
Dr. Ruth Hardman, Urologist, NHS: “Tadalafil is an excellent option for many men because it combines efficacy with a long duration, allowing sexual spontaneity. For those with prostate symptoms, it’s a practical dual-treatment.”
Mr. Mark Bentley, Pharmacist: “Most men tolerate Tadalafil well. It’s vital to discuss your health and medications with a pharmacist, especially if buying online, to avoid dangerous interactions.”
Frequently Asked Questions About Tadalafil
- Can I take Tadalafil daily?
- Yes, for some men a daily low dose (2.5 mg or 5 mg) is recommended. This enables sexual readiness at any time. Discuss with your GP if this is suitable for you.
- Does Tadalafil work the first time?
- Most men experience effect the first time, but results can vary. Sometimes a few attempts are required to find the optimal dose or timing.
- How long does Tadalafil last?
- The effects can last up to 36 hours (“weekend pill”), but it does not cause a constant erection; sexual stimulation is necessary.
- Is generic Tadalafil as effective as Cialis?
- Yes. All licensed generics meet the same UK and EU medical standards for quality, safety, and effectiveness (NHS: Tadalafil).
- Can I buy Tadalafil without a prescription in the UK?
- No. Genuine Tadalafil is prescription-only. Avoid unregulated sources online due to the risk of counterfeit and unsafe products (MHRA guidance).
Where to Buy Tadalafil Safely in the UK?
Prescription Tadalafil should always be purchased from a reputable, regulated source. Avoid counterfeit or unlicensed sellers. For a reliable and discreet pharmacy service, buy Tadalafil safely on our site. We guarantee:
- UK-licensed prescribers and genuine medicine
- Discreet packaging and fast delivery
- Pharmacist support and advice
Looking to order Tadalafil online with confidence? Click here to get started!
Tadalafil and Lifestyle: Maximising Results
Tadalafil works best as part of a healthy lifestyle. To enhance effectiveness, consider the following:
- Maintain a healthy weight and balanced diet
- Consider regular exercise for circulation health
- Limit alcohol and avoid recreational drugs
- Manage stress and communicate with your partner
Additional Uses: Beyond Erectile Dysfunction
Tadalafil is also used (under specialist supervision) for:
- Pulmonary arterial hypertension (at much higher doses)
- Raynaud’s phenomenon (off-label)
- Investigational uses in some urological conditions
Always seek expert guidance for these uses.
Key Facts Table: Tadalafil at a Glance
| Feature | Details |
|---|---|
| Type | PDE5 inhibitor |
| Prescription needed? | Yes, in the UK |
| How to take | Oral tablet, with or without food |
| How long does it last? | Up to 36 hours per dose |
| Minimum age | 18 years |
| Is it safe? | Yes, when prescribed by a healthcare professional |
Citations & Resources
- NHS: Tadalafil
- European Medicines Agency: Cialis
- British National Formulary (BNF): Tadalafil
- MHRA: Medicines Regulation
